Nortriptyline will add to the effects of alcohol and other depressants. This list is not complete and there are many other medicines that can interact with nortriptyline. The use of digitalis and or physostigmine may be considered in case of serious cardiovascular abnormalities or cardiac failure. Withdrawal Symptoms Though these are not indicative of addiction, abrupt cessation of treatment after prolonged therapy may produce nausea, headache, and malaise. Depression and certain other psychiatric disorders are themselves associated with an increased risk of suicide. The efficacy of tranylcypromine, nortriptyline, thioridazine osto nortriptyline and amitriptyline in two syndromological types of endogenous depression: comparison: Activitas Nervosa Superior Vol 23 Sep 1981, 198-200. Sequential trial comparing two plasma levels of nortriptyline: Australian and New Zealand Journal of Psychiatry Vol Mar 1974, 21-23.