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Take the regular oral tablet Clozaril with full glass of water. However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses. Clozapine is generally reserved for secondary use due to its propensity to cause serious side effects, such as life-threatening agranulocytosis and the necessity for life-long blood monitoring. While many patients may respond adequately at doses between 300 to 600 mg day, it may be necessary to raise the dose to the 600 to 900 mg day range to kobe clozapine piller obtain an acceptable response.